RESEARCH ARTICLE
Nobel Med 2019; 15(1): 41-46
EFFECT OF LINOPIRDINE ON FORCED SWIMMING TEST IN RATS
Barış Uzunok, Nevzat Kahveci, Güldal Güleç Süyen, M. Çağatay BüyükuysalABSTRACT
Material and Method: For this purpose, on the second day of the swimming test, rats received %0.9 NaCl (4 µl) or a Kv7 type voltage-gated potassium channel blocker linopirdine (0.1, 1, 10 µg/4 µl) intracerebroventricularly (i.c.v.), 15 min before the test.
Results: Linopirdine at a dose of 0.1 µg/4 µl significantly decreased immobilisation (p=0.003) and significantly
increased swimming (p<0.01) with respect to the control grup. Linopirdine at the doses of 1 µg/4 µl and 10 µg/4 µl; i.c.v., significantly decreased immobilisation (p values< 0.001) and significantly increased swimming (p=0.003 and p=0.021, respectively), and climbing (p=0.009 and p=0.006, respectively) with respect to the control grup.
Conclusion: The results we obtained shows that linopirdine applied through i.c.v way produces similar effects as the anti-depressant drugs in the FST model. Therefore, we believe that drugs that block Kv7 type voltage-gated potassium channels can be considered as antidepressant drug targets.
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Pubmed Style
Barış Uzunok, Nevzat Kahveci, Güldal Güleç Süyen, M. Çağatay Büyükuysal. [LİNOPİRDİN’İN SIÇANLARDA ZORLU YÜZME TESTİNDE GÖZLENEN ETKİLERİ]. Nobel Med 2019; 15(1): 41-46, Turkish. -
Web Style
Barış Uzunok, Nevzat Kahveci, Güldal Güleç Süyen, M. Çağatay Büyükuysal. [LİNOPİRDİN’İN SIÇANLARDA ZORLU YÜZME TESTİNDE GÖZLENEN ETKİLERİ]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish. -
AMA (American Medical Association) Style
Barış Uzunok, Nevzat Kahveci, Güldal Güleç Süyen, M. Çağatay Büyükuysal. [LİNOPİRDİN’İN SIÇANLARDA ZORLU YÜZME TESTİNDE GÖZLENEN ETKİLERİ]. Nobel Med 2019; 15(1): 41-46, Turkish. -
Vancouver/ICMJE Style
Barış Uzunok, Nevzat Kahveci, Güldal Güleç Süyen, M. Çağatay Büyükuysal. [LİNOPİRDİN’İN SIÇANLARDA ZORLU YÜZME TESTİNDE GÖZLENEN ETKİLERİ]. Nobel Med (2019); 15(1): 41-46, [cited Mayıs 24, 2021], Turkish. -
Harvard Style
Barış Uzunok, Nevzat Kahveci, Güldal Güleç Süyen, M. Çağatay Büyükuysal. (2019) [LİNOPİRDİN’İN SIÇANLARDA ZORLU YÜZME TESTİNDE GÖZLENEN ETKİLERİ]. Nobel Med, 15(1): 41-46, Turkish.