REVIEW
Nobel Med 2013; 9(2): 10-14

AGING KIDNEY: SENESCENCE OR DISEASE?

Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk
ABSTRACT
With the increased life expectancy of humans, the physicians are faced to more and more elderly patients. Kidneys change both structurally and functionally with age. Hyalinosis of arterioles and fibrous intimal thickening of the arteries leading to sclerosis, decreased number of nephrons, increased percentage of sclerotic glomeruli, progressive interstitial fibrosis, increased renal vascular resistance, decreased glomerular filtration rate, increased filtration pressure, podocyte damage, decreased concentration ability and hyporeninemic hypoaldosteronism are among these changes. The major clinical reflections of these changes are globally decreased renal function, mild proteinuria, distorted fluid and electrolyte balance with mild polyuria, hyponatremia and hyperkalemia. It is still unclear whether aging alone is responsible for decline in renal function in elderly; or this deterioration is due to comorbidities common in this population. Pathogenesis of aging-related changes in renal function is not fully elucidated; but genetic factors, recurrent attacks of acute kidney injury, aggressive strategies to lower blood pressure, accumulation of advanced glycosylation end products, decreased PPAR-γ expression, increased endothelin-1 expression, reduced nitric oxide generation and accumulation of asymmetric dimethylarginine were reported to have a role in the mechanism. Whatever this mechanism is; it is vital to treat elderly patients with great caution knowing that overtime these possible changes might occur with kidney functions.

LIVER AND SYSTEMIC DISEASES

05-09

Sebati Özdemir

REVIEW Nobel Med 2013; 9(2): 5-9

AGING KIDNEY: SENESCENCE OR DISEASE?

10-14

Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk

REVIEW Nobel Med 2013; 9(2): 10-14

IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS

15-20

Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş

RESEARCH ARTICLE Nobel Med 2013; 9(2): 15-20

EVALUATION OF PHYSICAL GROWTH IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

21-25

Celalettin Koşan, Oğuzhan Sepetçigil, Atilla Çayır, Avni Kaya, Behzat Özkan

RESEARCH ARTICLE Nobel Med 2013; 9(2): 21-25

COMPARISON OF RISK INDEXES USED IN DETERMINING THE POSTOPERATIVE RESPIRATORY INSUFFICIENCY RISK

26-31

Gülsüm Kavalcı, Cavidan Arar, Alkın Çolak, Nesrin Turan, Cemil Kavalcı

RESEARCH ARTICLE Nobel Med 2013; 9(2): 26-31

THE EVALUATION OF PRENATAL AND ENVIROMENTAL RISK FACTORS IN CHILDREN WITH ASTHMA, ALLERGIC RHINITIS AND BRONCHIAL ASTHMA ABSTRACT

32-37

Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir

RESEARCH ARTICLE Nobel Med 2013; 9(2): 32-37

REOPERATIONS AND MORBIDITY IN THYROID SURGERY

38-42

Serkan Teksöz, Murat Özcan, Aytül Sargan, Yusuf Bukey, Recep Özgültekin, Ateş Özyeğin

RESEARCH ARTICLE Nobel Med 2013; 9(2): 38-42

EFFECTS OF RAMADAN FASTING ON BLOOD PRESSURE CONTROL, LIPID PROFILE, BRAIN NATRIURETIC PEPTIDE, RENAL FUNCTIONS AND ELECTROLYTE LEVELS IN HYPERTENSIVE PATIENTS TAKING COMBINATION THERAPY

43-46

İbrahim Faruk Aktürk, İsmail Bıyık, Cüneyt Koşaş, Ahmet Arif Yalçın, Mehmet Ertürk, Fatih Uzun

RESEARCH ARTICLE Nobel Med 2013; 9(2): 43-46

MANAGEMENT OF A LARGE OUTBREAK CAUSED BY NOROVIRUS AND CAMPYLOBACTER JEJUNI OCCURRED IN A RURAL AREA IN TURKEY

47-51

İbak Gönen

RESEARCH ARTICLE Nobel Med 2013; 9(2): 47-51

FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES

52-56

Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu

RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56

EVALUATION OF ONE YEAR RESPONSE OF TREATMENT NAIVE CHRONIC HEPATITIS B PATIENTS TO 245 MG/DAY TENOFOVIR DISOPROXIL FUMARATE

57-62

Nazlım Aktuğ Demir, Servet Kölgelier, Lütfi Saltuk Demir, Şua Sümer, Nebahat Dikici, Serap Özçimen, Ahmet Çağkan İnkaya

RESEARCH ARTICLE Nobel Med 2013; 9(2): 57-62

THE RELATIONSHIP OF BONE MINERAL DENSITY WITH CAROTID INTIMA-MEDIA THICKNESS AND HEMODYNAMICS

63-68

Ramazan Büyükkaya, Selma Yazıcı, Beşir Erdoğmuş, Safinaz Ataoğlu, Mustafa Özşahin, Ayla Büyükkaya, Ömer Yazgan, Sibel Yazgan

RESEARCH ARTICLE Nobel Med 2013; 9(2): 63-68

MICROBIOLOGICAL EXAMINATION OF BLACK MUSSELS (MYTILUS GALLOPROVINCIALIS) CAUGHT IN DARDANELLES

69-73

Alper Şener, Neslihan Demir, Nesrin Çakıcı, Hasan Çakıcı, Hasan Kaya, Coşkun Bakar

RESEARCH ARTICLE Nobel Med 2013; 9(2): 69-73

THE IMPORTANCE OF EXAMINING ANTINUCLEAR ANTIBODY (ANA) IN NEUROLOGICAL DISEASES

74-78

Banu Özen Barut, Ufuk Emre, Ayşe Semra Demir, Aysun Ünal, İshak Tekin

RESEARCH ARTICLE Nobel Med 2013; 9(2): 74-78

THE EFFICACY OF NUTRITIONAL AND INFLAMMATORY MARKERS IN LENGTH OF HOSPITAL STAY AND MORTALITY PREDICTION IN SEVERELY MALNOURISHED PATIENTS

79-85

Osman Ekinci, Berna Terzioğlu, Seçkin Özgür Tekeli, Elvan Yılmaz, Turhan Çaşkurlu

RESEARCH ARTICLE Nobel Med 2013; 9(2): 79-85

DIAGNOSTIC VALUES OF ANAMNESIS AND PHYSICAL EXAMINATION FINDINGS IN ACUTE ABDOMINAL PAIN AND ACUTE APPENDICITIS IN CHILDREN ABSTRACT

86-90

Gülser Esen Besli, Suat Biçer, Özlem Kalaycık, Necmiye Keser, Şeyma Özkanlı, Coşkun Saf, Müferet Ergüven, Ayça Vitrinel

RESEARCH ARTICLE Nobel Med 2013; 9(2): 86-90

AN EVALUATION OF THE NECESSITY OF COMPUTED TOMOGRAPHY USED FOR THE CERVICAL SPINE ASSESSMENT OF THE PATIENTS WHO PRESENT WITH TRAUMA IN THE PEDIATRIC EMERGENCY DEPARTMENT

91-95

Ahmet İmerci, Umut Canbek, Muhammet Bozoğlan, Ahmet Kaya, Levent Sürer, Hakan Korkmaz, Hüseyin Tamer Ursavaş

RESEARCH ARTICLE Nobel Med 2013; 9(2): 91-95

THE EFFECT OF BOSENTAN ON PLASMA ISCHEMIA-MODIFIED ALBUMIN LEVELS IN ACUTE MESENTERIC ISCHEMIA

96-99

Kamil Gülpınar, Süleyman Özdemir, Erpulat Öziş, Sinan Aydın, Atilla Korkmaz

RESEARCH ARTICLE Nobel Med 2013; 9(2): 96-99

COULD APOMORPHINE BE AN EFFECTIVE TREATMENT OPTION FOR REFRACTORY TREMOR IN PARKINSON’S DISEASE? A PILOT STUDY

100-103

Nilgün Çınar, Şevki Şahin, Sibel Karşıdağ

RESEARCH ARTICLE Nobel Med 2013; 9(2): 100-103

EFFECTIVENESS OF ULTRASOUND IN THE TREATMENT OF SUBACROMIAL IMPINGEMENT SYNDROME

104-108

Türkan Akın, Nil Sayıner Çağlar, Özer Burnaz, Özgü Kesmezacar

RESEARCH ARTICLE Nobel Med 2013; 9(2): 104-108

PLASMA LEPTIN STATUS AND THE RELATIONSHIP BETWEEN DIFFERENT MEDICAL TREATMENTS USED IN ANKYLOSING SPONDYLITIS

109-113

Mustafa Güler, Erhan Çapkın, Murat Karkucak, Teoman Aydın, Ayşegül Küçükali Türkyılmaz, Adem Karaca, Ferhat Gökmen, Ahmet Alver, Emine Poyraz

RESEARCH ARTICLE Nobel Med 2013; 9(2): 109-113

A PILOT STUDY ABOUT QUALITY OF INFORMATION AT HEALTH RELATED IN TURKISH WEB SITES: MENISCUS TEAR

114-117

Fatih Küçükdurmaz, Mahmut Nedim Aytekin, İbrahim Tuncay, Cengiz Şen

RESEARCH ARTICLE Nobel Med 2013; 9(2): 114-117

TYPE-1 FRONTAL FIBROHYALINIZED PAROSTEAL (PERIOSTEAL) LIPOMA

118-121

Betül Taş, Karaca Başaran, Özgür Pilancı, Mehmet Öncü, Mehmet Sar

REPORT Nobel Med 2013; 9(2): 118-121

NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID)-RELATED COLOPATHY MIMICKING NEOPLASIA: CT FINDINGS

122-125

Gülgün Engin, Dilek Şahin, Emre Balık

REPORT Nobel Med 2013; 9(2): 122-125

A CASE OF SJOGREN’S SYNDROME ACCOMPANIED BY SIGNS OF NON-CARDIAC PULMONARY EDEMA AND INFECTION

126-129

Şua Sümer, Pakize Başak Efe, Onur Ural, Sema Yılmaz

REPORT Nobel Med 2013; 9(2): 126-129

ORD. PROF. DR. ERICH FRANK (1884-1957)

130-134

Arın Namal

A PORTRAIT Nobel Med 2013; 9(2): 130-134

LIVER AND SYSTEMIC DISEASES

05-09

Sebati Özdemir

REVIEW Nobel Med 2013; 9(2): 5-9

AGING KIDNEY: SENESCENCE OR DISEASE?

10-14

Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk

REVIEW Nobel Med 2013; 9(2): 10-14

IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS

15-20

Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş

RESEARCH ARTICLE Nobel Med 2013; 9(2): 15-20

EVALUATION OF PHYSICAL GROWTH IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

21-25

Celalettin Koşan, Oğuzhan Sepetçigil, Atilla Çayır, Avni Kaya, Behzat Özkan

RESEARCH ARTICLE Nobel Med 2013; 9(2): 21-25

COMPARISON OF RISK INDEXES USED IN DETERMINING THE POSTOPERATIVE RESPIRATORY INSUFFICIENCY RISK

26-31

Gülsüm Kavalcı, Cavidan Arar, Alkın Çolak, Nesrin Turan, Cemil Kavalcı

RESEARCH ARTICLE Nobel Med 2013; 9(2): 26-31

THE EVALUATION OF PRENATAL AND ENVIROMENTAL RISK FACTORS IN CHILDREN WITH ASTHMA, ALLERGIC RHINITIS AND BRONCHIAL ASTHMA ABSTRACT

32-37

Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir

RESEARCH ARTICLE Nobel Med 2013; 9(2): 32-37

REOPERATIONS AND MORBIDITY IN THYROID SURGERY

38-42

Serkan Teksöz, Murat Özcan, Aytül Sargan, Yusuf Bukey, Recep Özgültekin, Ateş Özyeğin

RESEARCH ARTICLE Nobel Med 2013; 9(2): 38-42

EFFECTS OF RAMADAN FASTING ON BLOOD PRESSURE CONTROL, LIPID PROFILE, BRAIN NATRIURETIC PEPTIDE, RENAL FUNCTIONS AND ELECTROLYTE LEVELS IN HYPERTENSIVE PATIENTS TAKING COMBINATION THERAPY

43-46

İbrahim Faruk Aktürk, İsmail Bıyık, Cüneyt Koşaş, Ahmet Arif Yalçın, Mehmet Ertürk, Fatih Uzun

RESEARCH ARTICLE Nobel Med 2013; 9(2): 43-46

MANAGEMENT OF A LARGE OUTBREAK CAUSED BY NOROVIRUS AND CAMPYLOBACTER JEJUNI OCCURRED IN A RURAL AREA IN TURKEY

47-51

İbak Gönen

RESEARCH ARTICLE Nobel Med 2013; 9(2): 47-51

FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES

52-56

Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu

RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56
  • Pubmed Style
    Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk. [YAŞLANAN BÖBREK: YAŞLANMA MI, HASTALIK MI?]. Nobel Med 2013; 9(2): 10-14, Turkish.
  • Web Style
    Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk. [YAŞLANAN BÖBREK: YAŞLANMA MI, HASTALIK MI?]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish.
  • AMA (American Medical Association) Style
    Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk. [YAŞLANAN BÖBREK: YAŞLANMA MI, HASTALIK MI?]. Nobel Med 2013; 9(2): 10-14, Turkish.
  • Vancouver/ICMJE Style
    Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk. [YAŞLANAN BÖBREK: YAŞLANMA MI, HASTALIK MI?]. Nobel Med (2013); 9(2): 10-14, [cited Mayıs 24, 2021], Turkish.
  • Harvard Style
    Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk. (2013) [YAŞLANAN BÖBREK: YAŞLANMA MI, HASTALIK MI?]. Nobel Med, 9(2): 10-14, Turkish.