RESEARCH ARTICLE
Nobel Med 2013; 9(2): 15-20

IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS

Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş
ABSTRACT
Objective: Subclinical vitamin B12 deficiency and adverse health outcomes are of general concern. Current biomarkers of vitamin B12 status are not always satisfactory to decide on a deficiency state. Recently, holotranscobalamin (holoTC) has been proposed as a useful alternative indicator of vitamin B12 status, however studies on its value in diagnosing cobalamin deficiency have not come to a conclusion yet. The purpose of this study is to investigate the usefulness of holoTC measurement together with total vitamin B12 measurement in diagnosing cobalamin deficiency, in a cross-sectional analysis.

Material and Method: Four hundred volunteers were grouped according to vitamin B12 levels as vitamin B12 deficient (vit B12<193 pg/ml, n=168), borderline (vit B12<193-300 pg/ml, n=100) and controls (vit B12>300 pg/ml, n=132). These groups were divided into two subgroups (A and B) according to holoTC cut-off value (35 pmol/L). The diagnostic efficacy of vitamin B12, holoTC and a combination of both measures were evaluated. Serum folate and homocysteine (Hcy) were used as indicators of vitamin B12 deficiency.

Results: Significantly higher Hcy and lower folate levels were observed in both vitamin B12 deficient and borderline B12 groups provided that holoTC levels were low.

Conclusion: Evaluation of vitamin B12 measures together with holoTC measures provides a more accurate diagnosis, especially in patients with borderline- B12 concentrations.
Keywords
Vitamin B12 Holotranscobalamin Homocysteine Folate

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  • Pubmed Style
    Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş. [IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS]. Nobel Med 2013; 9(2): 15-20, English.
  • Web Style
    Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş. [IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English.
  • AMA (American Medical Association) Style
    Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş. [IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS]. Nobel Med 2013; 9(2): 15-20, English.
  • Vancouver/ICMJE Style
    Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş. [IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS]. Nobel Med (2013); 9(2): 15-20, [cited Mayıs 24, 2021], English.
  • Harvard Style
    Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş. (2013) [IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS]. Nobel Med, 9(2): 15-20, English.