RESEARCH ARTICLE
Nobel Med 2013; 9(2): 15-20

IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS

Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş
ABSTRACT
Objective: Subclinical vitamin B12 deficiency and adverse health outcomes are of general concern. Current biomarkers of vitamin B12 status are not always satisfactory to decide on a deficiency state. Recently, holotranscobalamin (holoTC) has been proposed as a useful alternative indicator of vitamin B12 status, however studies on its value in diagnosing cobalamin deficiency have not come to a conclusion yet. The purpose of this study is to investigate the usefulness of holoTC measurement together with total vitamin B12 measurement in diagnosing cobalamin deficiency, in a cross-sectional analysis.

Material and Method: Four hundred volunteers were grouped according to vitamin B12 levels as vitamin B12 deficient (vit B12<193 pg/ml, n=168), borderline (vit B12<193-300 pg/ml, n=100) and controls (vit B12>300 pg/ml, n=132). These groups were divided into two subgroups (A and B) according to holoTC cut-off value (35 pmol/L). The diagnostic efficacy of vitamin B12, holoTC and a combination of both measures were evaluated. Serum folate and homocysteine (Hcy) were used as indicators of vitamin B12 deficiency.

Results: Significantly higher Hcy and lower folate levels were observed in both vitamin B12 deficient and borderline B12 groups provided that holoTC levels were low.

Conclusion: Evaluation of vitamin B12 measures together with holoTC measures provides a more accurate diagnosis, especially in patients with borderline- B12 concentrations.

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AGING KIDNEY: SENESCENCE OR DISEASE?

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Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk

REVIEW Nobel Med 2013; 9(2): 10-14

IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS

15-20

Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş

RESEARCH ARTICLE Nobel Med 2013; 9(2): 15-20

EVALUATION OF PHYSICAL GROWTH IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

21-25

Celalettin Koşan, Oğuzhan Sepetçigil, Atilla Çayır, Avni Kaya, Behzat Özkan

RESEARCH ARTICLE Nobel Med 2013; 9(2): 21-25

COMPARISON OF RISK INDEXES USED IN DETERMINING THE POSTOPERATIVE RESPIRATORY INSUFFICIENCY RISK

26-31

Gülsüm Kavalcı, Cavidan Arar, Alkın Çolak, Nesrin Turan, Cemil Kavalcı

RESEARCH ARTICLE Nobel Med 2013; 9(2): 26-31

THE EVALUATION OF PRENATAL AND ENVIROMENTAL RISK FACTORS IN CHILDREN WITH ASTHMA, ALLERGIC RHINITIS AND BRONCHIAL ASTHMA ABSTRACT

32-37

Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir

RESEARCH ARTICLE Nobel Med 2013; 9(2): 32-37

REOPERATIONS AND MORBIDITY IN THYROID SURGERY

38-42

Serkan Teksöz, Murat Özcan, Aytül Sargan, Yusuf Bukey, Recep Özgültekin, Ateş Özyeğin

RESEARCH ARTICLE Nobel Med 2013; 9(2): 38-42

EFFECTS OF RAMADAN FASTING ON BLOOD PRESSURE CONTROL, LIPID PROFILE, BRAIN NATRIURETIC PEPTIDE, RENAL FUNCTIONS AND ELECTROLYTE LEVELS IN HYPERTENSIVE PATIENTS TAKING COMBINATION THERAPY

43-46

İbrahim Faruk Aktürk, İsmail Bıyık, Cüneyt Koşaş, Ahmet Arif Yalçın, Mehmet Ertürk, Fatih Uzun

RESEARCH ARTICLE Nobel Med 2013; 9(2): 43-46

MANAGEMENT OF A LARGE OUTBREAK CAUSED BY NOROVIRUS AND CAMPYLOBACTER JEJUNI OCCURRED IN A RURAL AREA IN TURKEY

47-51

İbak Gönen

RESEARCH ARTICLE Nobel Med 2013; 9(2): 47-51

FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES

52-56

Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu

RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56

EVALUATION OF ONE YEAR RESPONSE OF TREATMENT NAIVE CHRONIC HEPATITIS B PATIENTS TO 245 MG/DAY TENOFOVIR DISOPROXIL FUMARATE

57-62

Nazlım Aktuğ Demir, Servet Kölgelier, Lütfi Saltuk Demir, Şua Sümer, Nebahat Dikici, Serap Özçimen, Ahmet Çağkan İnkaya

RESEARCH ARTICLE Nobel Med 2013; 9(2): 57-62

THE RELATIONSHIP OF BONE MINERAL DENSITY WITH CAROTID INTIMA-MEDIA THICKNESS AND HEMODYNAMICS

63-68

Ramazan Büyükkaya, Selma Yazıcı, Beşir Erdoğmuş, Safinaz Ataoğlu, Mustafa Özşahin, Ayla Büyükkaya, Ömer Yazgan, Sibel Yazgan

RESEARCH ARTICLE Nobel Med 2013; 9(2): 63-68

MICROBIOLOGICAL EXAMINATION OF BLACK MUSSELS (MYTILUS GALLOPROVINCIALIS) CAUGHT IN DARDANELLES

69-73

Alper Şener, Neslihan Demir, Nesrin Çakıcı, Hasan Çakıcı, Hasan Kaya, Coşkun Bakar

RESEARCH ARTICLE Nobel Med 2013; 9(2): 69-73

THE IMPORTANCE OF EXAMINING ANTINUCLEAR ANTIBODY (ANA) IN NEUROLOGICAL DISEASES

74-78

Banu Özen Barut, Ufuk Emre, Ayşe Semra Demir, Aysun Ünal, İshak Tekin

RESEARCH ARTICLE Nobel Med 2013; 9(2): 74-78

THE EFFICACY OF NUTRITIONAL AND INFLAMMATORY MARKERS IN LENGTH OF HOSPITAL STAY AND MORTALITY PREDICTION IN SEVERELY MALNOURISHED PATIENTS

79-85

Osman Ekinci, Berna Terzioğlu, Seçkin Özgür Tekeli, Elvan Yılmaz, Turhan Çaşkurlu

RESEARCH ARTICLE Nobel Med 2013; 9(2): 79-85

DIAGNOSTIC VALUES OF ANAMNESIS AND PHYSICAL EXAMINATION FINDINGS IN ACUTE ABDOMINAL PAIN AND ACUTE APPENDICITIS IN CHILDREN ABSTRACT

86-90

Gülser Esen Besli, Suat Biçer, Özlem Kalaycık, Necmiye Keser, Şeyma Özkanlı, Coşkun Saf, Müferet Ergüven, Ayça Vitrinel

RESEARCH ARTICLE Nobel Med 2013; 9(2): 86-90

AN EVALUATION OF THE NECESSITY OF COMPUTED TOMOGRAPHY USED FOR THE CERVICAL SPINE ASSESSMENT OF THE PATIENTS WHO PRESENT WITH TRAUMA IN THE PEDIATRIC EMERGENCY DEPARTMENT

91-95

Ahmet İmerci, Umut Canbek, Muhammet Bozoğlan, Ahmet Kaya, Levent Sürer, Hakan Korkmaz, Hüseyin Tamer Ursavaş

RESEARCH ARTICLE Nobel Med 2013; 9(2): 91-95

THE EFFECT OF BOSENTAN ON PLASMA ISCHEMIA-MODIFIED ALBUMIN LEVELS IN ACUTE MESENTERIC ISCHEMIA

96-99

Kamil Gülpınar, Süleyman Özdemir, Erpulat Öziş, Sinan Aydın, Atilla Korkmaz

RESEARCH ARTICLE Nobel Med 2013; 9(2): 96-99

COULD APOMORPHINE BE AN EFFECTIVE TREATMENT OPTION FOR REFRACTORY TREMOR IN PARKINSON’S DISEASE? A PILOT STUDY

100-103

Nilgün Çınar, Şevki Şahin, Sibel Karşıdağ

RESEARCH ARTICLE Nobel Med 2013; 9(2): 100-103

EFFECTIVENESS OF ULTRASOUND IN THE TREATMENT OF SUBACROMIAL IMPINGEMENT SYNDROME

104-108

Türkan Akın, Nil Sayıner Çağlar, Özer Burnaz, Özgü Kesmezacar

RESEARCH ARTICLE Nobel Med 2013; 9(2): 104-108

PLASMA LEPTIN STATUS AND THE RELATIONSHIP BETWEEN DIFFERENT MEDICAL TREATMENTS USED IN ANKYLOSING SPONDYLITIS

109-113

Mustafa Güler, Erhan Çapkın, Murat Karkucak, Teoman Aydın, Ayşegül Küçükali Türkyılmaz, Adem Karaca, Ferhat Gökmen, Ahmet Alver, Emine Poyraz

RESEARCH ARTICLE Nobel Med 2013; 9(2): 109-113

A PILOT STUDY ABOUT QUALITY OF INFORMATION AT HEALTH RELATED IN TURKISH WEB SITES: MENISCUS TEAR

114-117

Fatih Küçükdurmaz, Mahmut Nedim Aytekin, İbrahim Tuncay, Cengiz Şen

RESEARCH ARTICLE Nobel Med 2013; 9(2): 114-117

TYPE-1 FRONTAL FIBROHYALINIZED PAROSTEAL (PERIOSTEAL) LIPOMA

118-121

Betül Taş, Karaca Başaran, Özgür Pilancı, Mehmet Öncü, Mehmet Sar

REPORT Nobel Med 2013; 9(2): 118-121

NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID)-RELATED COLOPATHY MIMICKING NEOPLASIA: CT FINDINGS

122-125

Gülgün Engin, Dilek Şahin, Emre Balık

REPORT Nobel Med 2013; 9(2): 122-125

A CASE OF SJOGREN’S SYNDROME ACCOMPANIED BY SIGNS OF NON-CARDIAC PULMONARY EDEMA AND INFECTION

126-129

Şua Sümer, Pakize Başak Efe, Onur Ural, Sema Yılmaz

REPORT Nobel Med 2013; 9(2): 126-129

ORD. PROF. DR. ERICH FRANK (1884-1957)

130-134

Arın Namal

A PORTRAIT Nobel Med 2013; 9(2): 130-134

LIVER AND SYSTEMIC DISEASES

05-09

Sebati Özdemir

REVIEW Nobel Med 2013; 9(2): 5-9

AGING KIDNEY: SENESCENCE OR DISEASE?

10-14

Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk

REVIEW Nobel Med 2013; 9(2): 10-14

IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS

15-20

Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş

RESEARCH ARTICLE Nobel Med 2013; 9(2): 15-20

EVALUATION OF PHYSICAL GROWTH IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

21-25

Celalettin Koşan, Oğuzhan Sepetçigil, Atilla Çayır, Avni Kaya, Behzat Özkan

RESEARCH ARTICLE Nobel Med 2013; 9(2): 21-25

COMPARISON OF RISK INDEXES USED IN DETERMINING THE POSTOPERATIVE RESPIRATORY INSUFFICIENCY RISK

26-31

Gülsüm Kavalcı, Cavidan Arar, Alkın Çolak, Nesrin Turan, Cemil Kavalcı

RESEARCH ARTICLE Nobel Med 2013; 9(2): 26-31

THE EVALUATION OF PRENATAL AND ENVIROMENTAL RISK FACTORS IN CHILDREN WITH ASTHMA, ALLERGIC RHINITIS AND BRONCHIAL ASTHMA ABSTRACT

32-37

Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir

RESEARCH ARTICLE Nobel Med 2013; 9(2): 32-37

REOPERATIONS AND MORBIDITY IN THYROID SURGERY

38-42

Serkan Teksöz, Murat Özcan, Aytül Sargan, Yusuf Bukey, Recep Özgültekin, Ateş Özyeğin

RESEARCH ARTICLE Nobel Med 2013; 9(2): 38-42

EFFECTS OF RAMADAN FASTING ON BLOOD PRESSURE CONTROL, LIPID PROFILE, BRAIN NATRIURETIC PEPTIDE, RENAL FUNCTIONS AND ELECTROLYTE LEVELS IN HYPERTENSIVE PATIENTS TAKING COMBINATION THERAPY

43-46

İbrahim Faruk Aktürk, İsmail Bıyık, Cüneyt Koşaş, Ahmet Arif Yalçın, Mehmet Ertürk, Fatih Uzun

RESEARCH ARTICLE Nobel Med 2013; 9(2): 43-46

MANAGEMENT OF A LARGE OUTBREAK CAUSED BY NOROVIRUS AND CAMPYLOBACTER JEJUNI OCCURRED IN A RURAL AREA IN TURKEY

47-51

İbak Gönen

RESEARCH ARTICLE Nobel Med 2013; 9(2): 47-51

FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES

52-56

Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu

RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56
  • Pubmed Style
    Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş. [IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS]. Nobel Med 2013; 9(2): 15-20, English.
  • Web Style
    Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş. [IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English.
  • AMA (American Medical Association) Style
    Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş. [IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS]. Nobel Med 2013; 9(2): 15-20, English.
  • Vancouver/ICMJE Style
    Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş. [IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS]. Nobel Med (2013); 9(2): 15-20, [cited Mayıs 24, 2021], English.
  • Harvard Style
    Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş. (2013) [IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS]. Nobel Med, 9(2): 15-20, English.