FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES
Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah HaholuABSTRACT
Material and Method: Using conventional paraffin embedding, immunoperoxidase staining, we retrospectively investigated Ki67 index, CD99 and FLI-1 expressions in 42 DLBCL cases. For in situ detection of apoptosis, terminal deoxynucleotidyl transferase (TdT) -mediated dUTP nick-end labeling (TUNEL) technique was performed. Prechemoterapy primary tumors were used for in all cases study.
Results: Immunohistochemical expression of the proteins CD99 and FLI-1 was observed in 14/42 (33.3%) and 7/42 (16.7%) cases, respectively. Concomittant expressions of CD99 and FLI-1 proteins were found in 5/42 (11.9%) cases. The statistical analyses showed a significant positive correlation between Ki67 index and the immunohistochemical expressions of CD99 and FLI-1 (p=0.012 and p=0.046, respectively).
Conclusion: This study demonstrates that CD99 and FLI-1 are frequently expressed in DLBCL and in the differential diagnosis of CD99+ and FLI-1+ neoplasms, DLBCL should be considered. The relatively frequent expressions of CD99 and FLI-1 in DLBCL is unexpected, and their biologic and clinical significances have yet to be clarified.
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RESEARCH ARTICLE Nobel Med 2013; 9(2): 21-25COMPARISON OF RISK INDEXES USED IN DETERMINING THE POSTOPERATIVE RESPIRATORY INSUFFICIENCY RISK
26-31Gülsüm Kavalcı, Cavidan Arar, Alkın Çolak, Nesrin Turan, Cemil Kavalcı
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32-37Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir
RESEARCH ARTICLE Nobel Med 2013; 9(2): 32-37REOPERATIONS AND MORBIDITY IN THYROID SURGERY
38-42Serkan Teksöz, Murat Özcan, Aytül Sargan, Yusuf Bukey, Recep Özgültekin, Ateş Özyeğin
RESEARCH ARTICLE Nobel Med 2013; 9(2): 38-42EFFECTS OF RAMADAN FASTING ON BLOOD PRESSURE CONTROL, LIPID PROFILE, BRAIN NATRIURETIC PEPTIDE, RENAL FUNCTIONS AND ELECTROLYTE LEVELS IN HYPERTENSIVE PATIENTS TAKING COMBINATION THERAPY
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47-51İbak Gönen
RESEARCH ARTICLE Nobel Med 2013; 9(2): 47-51FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES
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RESEARCH ARTICLE Nobel Med 2013; 9(2): 57-62THE RELATIONSHIP OF BONE MINERAL DENSITY WITH CAROTID INTIMA-MEDIA THICKNESS AND HEMODYNAMICS
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74-78Banu Özen Barut, Ufuk Emre, Ayşe Semra Demir, Aysun Ünal, İshak Tekin
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130-134Arın Namal
A PORTRAIT Nobel Med 2013; 9(2): 130-134LIVER AND SYSTEMIC DISEASES
05-09Sebati Özdemir
REVIEW Nobel Med 2013; 9(2): 5-9AGING KIDNEY: SENESCENCE OR DISEASE?
10-14Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk
REVIEW Nobel Med 2013; 9(2): 10-14IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS
15-20Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş
RESEARCH ARTICLE Nobel Med 2013; 9(2): 15-20EVALUATION OF PHYSICAL GROWTH IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER
21-25Celalettin Koşan, Oğuzhan Sepetçigil, Atilla Çayır, Avni Kaya, Behzat Özkan
RESEARCH ARTICLE Nobel Med 2013; 9(2): 21-25COMPARISON OF RISK INDEXES USED IN DETERMINING THE POSTOPERATIVE RESPIRATORY INSUFFICIENCY RISK
26-31Gülsüm Kavalcı, Cavidan Arar, Alkın Çolak, Nesrin Turan, Cemil Kavalcı
RESEARCH ARTICLE Nobel Med 2013; 9(2): 26-31THE EVALUATION OF PRENATAL AND ENVIROMENTAL RISK FACTORS IN CHILDREN WITH ASTHMA, ALLERGIC RHINITIS AND BRONCHIAL ASTHMA ABSTRACT
32-37Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir
RESEARCH ARTICLE Nobel Med 2013; 9(2): 32-37REOPERATIONS AND MORBIDITY IN THYROID SURGERY
38-42Serkan Teksöz, Murat Özcan, Aytül Sargan, Yusuf Bukey, Recep Özgültekin, Ateş Özyeğin
RESEARCH ARTICLE Nobel Med 2013; 9(2): 38-42EFFECTS OF RAMADAN FASTING ON BLOOD PRESSURE CONTROL, LIPID PROFILE, BRAIN NATRIURETIC PEPTIDE, RENAL FUNCTIONS AND ELECTROLYTE LEVELS IN HYPERTENSIVE PATIENTS TAKING COMBINATION THERAPY
43-46İbrahim Faruk Aktürk, İsmail Bıyık, Cüneyt Koşaş, Ahmet Arif Yalçın, Mehmet Ertürk, Fatih Uzun
RESEARCH ARTICLE Nobel Med 2013; 9(2): 43-46MANAGEMENT OF A LARGE OUTBREAK CAUSED BY NOROVIRUS AND CAMPYLOBACTER JEJUNI OCCURRED IN A RURAL AREA IN TURKEY
47-51İbak Gönen
RESEARCH ARTICLE Nobel Med 2013; 9(2): 47-51FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES
52-56Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu
RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56-
Pubmed Style
Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu. [FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES]. Nobel Med 2013; 9(2): 52-56, English. -
Web Style
Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu. [FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English. -
AMA (American Medical Association) Style
Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu. [FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES]. Nobel Med 2013; 9(2): 52-56, English. -
Vancouver/ICMJE Style
Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu. [FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES]. Nobel Med (2013); 9(2): 52-56, [cited Mayıs 24, 2021], English. -
Harvard Style
Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu. (2013) [FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES]. Nobel Med, 9(2): 52-56, English.