THE EFFECT OF BOSENTAN ON PLASMA ISCHEMIA-MODIFIED ALBUMIN LEVELS IN ACUTE MESENTERIC ISCHEMIA
Kamil Gülpınar, Süleyman Özdemir, Erpulat Öziş, Sinan Aydın, Atilla KorkmazABSTRACT
Material and Method: In this randomized, controlled trial 36 mature female wistor rats were divided into three groups. Group 1 (n=12) was the control group which only laparotomy was performed. Group 2 (n=12) was the ischemia group and group 3 (n=12) was the bosentan pretreated (100 mg/kg-1 day, 1 gavage/day for two days before surgery) ischemia group. In the ischemia groups (GR 2 and GR 3) following laparotomy the superior mesenteric artery was clamped using a bulldog clamp during laparotomy. Blood samples were taken at 30 minutes from all groups and IMA levels were studied.
Results: Plasma IMA levels in the ischemia group (GR 2) was significantly higher compared to those of the control (p<0.001) and bosentan pretreated group (GR 3) (p=0.002). Serum IMA levels were higher in GR 3 than control group but there were no statistical significance (p=0.659).
Conclusion: These preliminary results suggest that bosentan might have a protective effect in mesenteric ischemic conditions.
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Pubmed Style
Kamil Gülpınar, Süleyman Özdemir, Erpulat Öziş, Sinan Aydın, Atilla Korkmaz. [THE EFFECT OF BOSENTAN ON PLASMA ISCHEMIA-MODIFIED ALBUMIN LEVELS IN ACUTE MESENTERIC ISCHEMIA]. Nobel Med 2013; 9(2): 96-99, English. -
Web Style
Kamil Gülpınar, Süleyman Özdemir, Erpulat Öziş, Sinan Aydın, Atilla Korkmaz. [THE EFFECT OF BOSENTAN ON PLASMA ISCHEMIA-MODIFIED ALBUMIN LEVELS IN ACUTE MESENTERIC ISCHEMIA]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English. -
AMA (American Medical Association) Style
Kamil Gülpınar, Süleyman Özdemir, Erpulat Öziş, Sinan Aydın, Atilla Korkmaz. [THE EFFECT OF BOSENTAN ON PLASMA ISCHEMIA-MODIFIED ALBUMIN LEVELS IN ACUTE MESENTERIC ISCHEMIA]. Nobel Med 2013; 9(2): 96-99, English. -
Vancouver/ICMJE Style
Kamil Gülpınar, Süleyman Özdemir, Erpulat Öziş, Sinan Aydın, Atilla Korkmaz. [THE EFFECT OF BOSENTAN ON PLASMA ISCHEMIA-MODIFIED ALBUMIN LEVELS IN ACUTE MESENTERIC ISCHEMIA]. Nobel Med (2013); 9(2): 96-99, [cited Mayıs 24, 2021], English. -
Harvard Style
Kamil Gülpınar, Süleyman Özdemir, Erpulat Öziş, Sinan Aydın, Atilla Korkmaz. (2013) [THE EFFECT OF BOSENTAN ON PLASMA ISCHEMIA-MODIFIED ALBUMIN LEVELS IN ACUTE MESENTERIC ISCHEMIA]. Nobel Med, 9(2): 96-99, English.