COULD APOMORPHINE BE AN EFFECTIVE TREATMENT OPTION FOR REFRACTORY TREMOR IN PARKINSON’S DISEASE? A PILOT STUDY
Nilgün Çınar, Şevki Şahin, Sibel KarşıdağABSTRACT
Treatment response was assessed with the motor section of the Unified Parkinson’s Disease rating scale (UPDRS). Tremor, rigidity and bradykinesia were scored by using specific items of the UPDRS.
Material and Method: The study group included 13 consecutive patients with Parkinson’s disease who have refractory tremor. Increasing doses of 1 mg, 2 mg, 4 mg subcutaneous apomorphine were used; peak improvement dose and UPDRS scores were determined after 30 minutes. The patients have used oral dopaminergic treatment plus subcutaneous apomorhine and they have been followed on weekly phone calls. The completion of the study was defined as the end of the 1st month. Finally, the UPDRS motor scores of the patients were compared to the basal scores.
Results: Three patients dropped out due to side effects. The average reduction rate of total UPDRS, tremor, bradykinesia and rigidity scores were found as 20.6%, 38.5%, 30.1% and 16.6% respectively. At the end of the first month, tremor, bradykinesia and rigidity scores were statistically improved in comparison to those of the baseline.
Conclusion: Subcutaneous apomorphine combined to oral dopaminergic medications may provide effective relief in serious and refractory rest tremor as well as bradykinesia and rigidity in selected Parkinson patients.
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RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56-
Pubmed Style
Nilgün Çınar, Şevki Şahin, Sibel Karşıdağ. [COULD APOMORPHINE BE AN EFFECTIVE TREATMENT OPTION FOR REFRACTORY TREMOR IN PARKINSON’S DISEASE? A PILOT STUDY]. Nobel Med 2013; 9(2): 100-103, English. -
Web Style
Nilgün Çınar, Şevki Şahin, Sibel Karşıdağ. [COULD APOMORPHINE BE AN EFFECTIVE TREATMENT OPTION FOR REFRACTORY TREMOR IN PARKINSON’S DISEASE? A PILOT STUDY]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], English. -
AMA (American Medical Association) Style
Nilgün Çınar, Şevki Şahin, Sibel Karşıdağ. [COULD APOMORPHINE BE AN EFFECTIVE TREATMENT OPTION FOR REFRACTORY TREMOR IN PARKINSON’S DISEASE? A PILOT STUDY]. Nobel Med 2013; 9(2): 100-103, English. -
Vancouver/ICMJE Style
Nilgün Çınar, Şevki Şahin, Sibel Karşıdağ. [COULD APOMORPHINE BE AN EFFECTIVE TREATMENT OPTION FOR REFRACTORY TREMOR IN PARKINSON’S DISEASE? A PILOT STUDY]. Nobel Med (2013); 9(2): 100-103, [cited Mayıs 24, 2021], English. -
Harvard Style
Nilgün Çınar, Şevki Şahin, Sibel Karşıdağ. (2013) [COULD APOMORPHINE BE AN EFFECTIVE TREATMENT OPTION FOR REFRACTORY TREMOR IN PARKINSON’S DISEASE? A PILOT STUDY]. Nobel Med, 9(2): 100-103, English.