EVALUATION OF ONE YEAR RESPONSE OF TREATMENT NAIVE CHRONIC HEPATITIS B PATIENTS TO 245 MG/DAY TENOFOVIR DISOPROXIL FUMARATE
Nazlım Aktuğ Demir, Servet Kölgelier, Lütfi Saltuk Demir, Şua Sümer, Nebahat Dikici, Serap Özçimen, Ahmet Çağkan İnkayaABSTRACT
Material and Method: This retrospective study included 201 treatment naive chronic hepatitis B patients who admitted to infectious diseases clinics of Adiyaman State Hospital, Adiyaman 82nd Year State Hospital and Selçuk University Selçuklu Medical Faculty between 01-Jan-2010 and 31-Dec-2011. Indication for biopsy was defined using American Association for the Study of Liver Disease (AASLD) criteria. Patient charts were retrospectively reviewed. Data were entered to SPSS 16.0 package program. Regarding statistical evaluation chi square test was used for cathegorical variables, and T test, Mann Whitney U test was used for continous variables. For analysis of repeated measurements variance analysis for repeated measures was used and significant groups were tested by signed rank test. p<0.05 was considered statistically significant.
Results: One hundred thirty eight (68.7%) patients were males, 63 (31.3%) were females, and mean age was 39.9±12.5. HBeAg was positive in 88 (43.8%) and anti-HBe was positive in 113 (56.2%) patients. Median value for HBV DNA was 52920000 (6032800-34x109) IU/mL, ALT was 98.0 (14.0-665.0) u/L. At 24th week HBV DNA level was below 400 copy/ml in 57% of HBeAg positive and 69.5% of HBeAg negative patients and at 48th week in 81.3% of HBeAg positive and 89% of HBeAg negative patients. At 24th week of treatment ALT level normalized in 64.4% of HBeAg positive and 67.3% of HBeAg negative patients and at 48th week in 83% of HBeAg positive and 79% of HBeAg negative patients. ALT, and HBV DNA values significantly decreased relative to controls. Follow up did not reveal any significant change in creatinine, phosphor, calcium and ALP values.
Conclusion: We conclude that TDF treatment was effective and safe during follow up. Because long term treatment is needed for CHB, more long term studies with big sample sizes are needed to determine effectiveness and side effects of tenofovir treatment.
LIVER AND SYSTEMIC DISEASES
05-09Sebati Özdemir
REVIEW Nobel Med 2013; 9(2): 5-9AGING KIDNEY: SENESCENCE OR DISEASE?
10-14Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk
REVIEW Nobel Med 2013; 9(2): 10-14IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS
15-20Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş
RESEARCH ARTICLE Nobel Med 2013; 9(2): 15-20EVALUATION OF PHYSICAL GROWTH IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER
21-25Celalettin Koşan, Oğuzhan Sepetçigil, Atilla Çayır, Avni Kaya, Behzat Özkan
RESEARCH ARTICLE Nobel Med 2013; 9(2): 21-25COMPARISON OF RISK INDEXES USED IN DETERMINING THE POSTOPERATIVE RESPIRATORY INSUFFICIENCY RISK
26-31Gülsüm Kavalcı, Cavidan Arar, Alkın Çolak, Nesrin Turan, Cemil Kavalcı
RESEARCH ARTICLE Nobel Med 2013; 9(2): 26-31THE EVALUATION OF PRENATAL AND ENVIROMENTAL RISK FACTORS IN CHILDREN WITH ASTHMA, ALLERGIC RHINITIS AND BRONCHIAL ASTHMA ABSTRACT
32-37Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir
RESEARCH ARTICLE Nobel Med 2013; 9(2): 32-37REOPERATIONS AND MORBIDITY IN THYROID SURGERY
38-42Serkan Teksöz, Murat Özcan, Aytül Sargan, Yusuf Bukey, Recep Özgültekin, Ateş Özyeğin
RESEARCH ARTICLE Nobel Med 2013; 9(2): 38-42EFFECTS OF RAMADAN FASTING ON BLOOD PRESSURE CONTROL, LIPID PROFILE, BRAIN NATRIURETIC PEPTIDE, RENAL FUNCTIONS AND ELECTROLYTE LEVELS IN HYPERTENSIVE PATIENTS TAKING COMBINATION THERAPY
43-46İbrahim Faruk Aktürk, İsmail Bıyık, Cüneyt Koşaş, Ahmet Arif Yalçın, Mehmet Ertürk, Fatih Uzun
RESEARCH ARTICLE Nobel Med 2013; 9(2): 43-46MANAGEMENT OF A LARGE OUTBREAK CAUSED BY NOROVIRUS AND CAMPYLOBACTER JEJUNI OCCURRED IN A RURAL AREA IN TURKEY
47-51İbak Gönen
RESEARCH ARTICLE Nobel Med 2013; 9(2): 47-51FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES
52-56Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu
RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56EVALUATION OF ONE YEAR RESPONSE OF TREATMENT NAIVE CHRONIC HEPATITIS B PATIENTS TO 245 MG/DAY TENOFOVIR DISOPROXIL FUMARATE
57-62Nazlım Aktuğ Demir, Servet Kölgelier, Lütfi Saltuk Demir, Şua Sümer, Nebahat Dikici, Serap Özçimen, Ahmet Çağkan İnkaya
RESEARCH ARTICLE Nobel Med 2013; 9(2): 57-62THE RELATIONSHIP OF BONE MINERAL DENSITY WITH CAROTID INTIMA-MEDIA THICKNESS AND HEMODYNAMICS
63-68Ramazan Büyükkaya, Selma Yazıcı, Beşir Erdoğmuş, Safinaz Ataoğlu, Mustafa Özşahin, Ayla Büyükkaya, Ömer Yazgan, Sibel Yazgan
RESEARCH ARTICLE Nobel Med 2013; 9(2): 63-68MICROBIOLOGICAL EXAMINATION OF BLACK MUSSELS (MYTILUS GALLOPROVINCIALIS) CAUGHT IN DARDANELLES
69-73Alper Şener, Neslihan Demir, Nesrin Çakıcı, Hasan Çakıcı, Hasan Kaya, Coşkun Bakar
RESEARCH ARTICLE Nobel Med 2013; 9(2): 69-73THE IMPORTANCE OF EXAMINING ANTINUCLEAR ANTIBODY (ANA) IN NEUROLOGICAL DISEASES
74-78Banu Özen Barut, Ufuk Emre, Ayşe Semra Demir, Aysun Ünal, İshak Tekin
RESEARCH ARTICLE Nobel Med 2013; 9(2): 74-78THE EFFICACY OF NUTRITIONAL AND INFLAMMATORY MARKERS IN LENGTH OF HOSPITAL STAY AND MORTALITY PREDICTION IN SEVERELY MALNOURISHED PATIENTS
79-85Osman Ekinci, Berna Terzioğlu, Seçkin Özgür Tekeli, Elvan Yılmaz, Turhan Çaşkurlu
RESEARCH ARTICLE Nobel Med 2013; 9(2): 79-85DIAGNOSTIC VALUES OF ANAMNESIS AND PHYSICAL EXAMINATION FINDINGS IN ACUTE ABDOMINAL PAIN AND ACUTE APPENDICITIS IN CHILDREN ABSTRACT
86-90Gülser Esen Besli, Suat Biçer, Özlem Kalaycık, Necmiye Keser, Şeyma Özkanlı, Coşkun Saf, Müferet Ergüven, Ayça Vitrinel
RESEARCH ARTICLE Nobel Med 2013; 9(2): 86-90AN EVALUATION OF THE NECESSITY OF COMPUTED TOMOGRAPHY USED FOR THE CERVICAL SPINE ASSESSMENT OF THE PATIENTS WHO PRESENT WITH TRAUMA IN THE PEDIATRIC EMERGENCY DEPARTMENT
91-95Ahmet İmerci, Umut Canbek, Muhammet Bozoğlan, Ahmet Kaya, Levent Sürer, Hakan Korkmaz, Hüseyin Tamer Ursavaş
RESEARCH ARTICLE Nobel Med 2013; 9(2): 91-95THE EFFECT OF BOSENTAN ON PLASMA ISCHEMIA-MODIFIED ALBUMIN LEVELS IN ACUTE MESENTERIC ISCHEMIA
96-99Kamil Gülpınar, Süleyman Özdemir, Erpulat Öziş, Sinan Aydın, Atilla Korkmaz
RESEARCH ARTICLE Nobel Med 2013; 9(2): 96-99COULD APOMORPHINE BE AN EFFECTIVE TREATMENT OPTION FOR REFRACTORY TREMOR IN PARKINSON’S DISEASE? A PILOT STUDY
100-103Nilgün Çınar, Şevki Şahin, Sibel Karşıdağ
RESEARCH ARTICLE Nobel Med 2013; 9(2): 100-103EFFECTIVENESS OF ULTRASOUND IN THE TREATMENT OF SUBACROMIAL IMPINGEMENT SYNDROME
104-108Türkan Akın, Nil Sayıner Çağlar, Özer Burnaz, Özgü Kesmezacar
RESEARCH ARTICLE Nobel Med 2013; 9(2): 104-108PLASMA LEPTIN STATUS AND THE RELATIONSHIP BETWEEN DIFFERENT MEDICAL TREATMENTS USED IN ANKYLOSING SPONDYLITIS
109-113Mustafa Güler, Erhan Çapkın, Murat Karkucak, Teoman Aydın, Ayşegül Küçükali Türkyılmaz, Adem Karaca, Ferhat Gökmen, Ahmet Alver, Emine Poyraz
RESEARCH ARTICLE Nobel Med 2013; 9(2): 109-113A PILOT STUDY ABOUT QUALITY OF INFORMATION AT HEALTH RELATED IN TURKISH WEB SITES: MENISCUS TEAR
114-117Fatih Küçükdurmaz, Mahmut Nedim Aytekin, İbrahim Tuncay, Cengiz Şen
RESEARCH ARTICLE Nobel Med 2013; 9(2): 114-117TYPE-1 FRONTAL FIBROHYALINIZED PAROSTEAL (PERIOSTEAL) LIPOMA
118-121Betül Taş, Karaca Başaran, Özgür Pilancı, Mehmet Öncü, Mehmet Sar
REPORT Nobel Med 2013; 9(2): 118-121NON-STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID)-RELATED COLOPATHY MIMICKING NEOPLASIA: CT FINDINGS
122-125Gülgün Engin, Dilek Şahin, Emre Balık
REPORT Nobel Med 2013; 9(2): 122-125A CASE OF SJOGREN’S SYNDROME ACCOMPANIED BY SIGNS OF NON-CARDIAC PULMONARY EDEMA AND INFECTION
126-129Şua Sümer, Pakize Başak Efe, Onur Ural, Sema Yılmaz
REPORT Nobel Med 2013; 9(2): 126-129ORD. PROF. DR. ERICH FRANK (1884-1957)
130-134Arın Namal
A PORTRAIT Nobel Med 2013; 9(2): 130-134LIVER AND SYSTEMIC DISEASES
05-09Sebati Özdemir
REVIEW Nobel Med 2013; 9(2): 5-9AGING KIDNEY: SENESCENCE OR DISEASE?
10-14Meltem Gürsu, Rümeyza Kazancıoğlu, Savaş Öztürk
REVIEW Nobel Med 2013; 9(2): 10-14IMPORTANCE OF HOLOTRANSCOBALAMIN (HOLOTC) MEASUREMENTS IN EARLY DIAGNOSIS OF COBALAMIN DEFICIENCY, ESPECIALLY IN PATIENTS WITH BORDERLINE VITAMIN B12 CONCENTRATIONS
15-20Faruk Sönmezışık, Esma Sürmen Gür, Burak Asıltaş
RESEARCH ARTICLE Nobel Med 2013; 9(2): 15-20EVALUATION OF PHYSICAL GROWTH IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER
21-25Celalettin Koşan, Oğuzhan Sepetçigil, Atilla Çayır, Avni Kaya, Behzat Özkan
RESEARCH ARTICLE Nobel Med 2013; 9(2): 21-25COMPARISON OF RISK INDEXES USED IN DETERMINING THE POSTOPERATIVE RESPIRATORY INSUFFICIENCY RISK
26-31Gülsüm Kavalcı, Cavidan Arar, Alkın Çolak, Nesrin Turan, Cemil Kavalcı
RESEARCH ARTICLE Nobel Med 2013; 9(2): 26-31THE EVALUATION OF PRENATAL AND ENVIROMENTAL RISK FACTORS IN CHILDREN WITH ASTHMA, ALLERGIC RHINITIS AND BRONCHIAL ASTHMA ABSTRACT
32-37Mehmet İbrahim Turan, Müferet Ergüven, Mehmet Özdemir
RESEARCH ARTICLE Nobel Med 2013; 9(2): 32-37REOPERATIONS AND MORBIDITY IN THYROID SURGERY
38-42Serkan Teksöz, Murat Özcan, Aytül Sargan, Yusuf Bukey, Recep Özgültekin, Ateş Özyeğin
RESEARCH ARTICLE Nobel Med 2013; 9(2): 38-42EFFECTS OF RAMADAN FASTING ON BLOOD PRESSURE CONTROL, LIPID PROFILE, BRAIN NATRIURETIC PEPTIDE, RENAL FUNCTIONS AND ELECTROLYTE LEVELS IN HYPERTENSIVE PATIENTS TAKING COMBINATION THERAPY
43-46İbrahim Faruk Aktürk, İsmail Bıyık, Cüneyt Koşaş, Ahmet Arif Yalçın, Mehmet Ertürk, Fatih Uzun
RESEARCH ARTICLE Nobel Med 2013; 9(2): 43-46MANAGEMENT OF A LARGE OUTBREAK CAUSED BY NOROVIRUS AND CAMPYLOBACTER JEJUNI OCCURRED IN A RURAL AREA IN TURKEY
47-51İbak Gönen
RESEARCH ARTICLE Nobel Med 2013; 9(2): 47-51FREQUENT CD99 AND FLI-1 EXPRESSIONS IN DIFFUSE LARGE B-CELL LYMPHOMA AND THEIR ASSOCIATION WITH PROLIFERATIVE AND APOPTOTIC RATES
52-56Ufuk Berber, İsmail Yılmaz, Tolga Tuncel, Zafer Küçükodacı Aptullah Haholu
RESEARCH ARTICLE Nobel Med 2013; 9(2): 52-56-
Pubmed Style
Nazlım Aktuğ Demir, Servet Kölgelier, Lütfi Saltuk Demir, Şua Sümer, Nebahat Dikici, Serap Özçimen, Ahmet Çağkan İnkaya. [NAİF KRONİK HEPATİT B HASTALARININ BİR YILLIK 245 MG/GÜN TENOFOVİR DİSOPROKSİL FUMARATE TEDAVİ SONUÇLARININ DEĞERLENDİRİLMESİ]. Nobel Med 2013; 9(2): 57-62, Turkish. -
Web Style
Nazlım Aktuğ Demir, Servet Kölgelier, Lütfi Saltuk Demir, Şua Sümer, Nebahat Dikici, Serap Özçimen, Ahmet Çağkan İnkaya. [NAİF KRONİK HEPATİT B HASTALARININ BİR YILLIK 245 MG/GÜN TENOFOVİR DİSOPROKSİL FUMARATE TEDAVİ SONUÇLARININ DEĞERLENDİRİLMESİ]. www.nobelmedicus.com/en/Article.aspx?m=1716 [Access: Mayıs 24, 2021], Turkish. -
AMA (American Medical Association) Style
Nazlım Aktuğ Demir, Servet Kölgelier, Lütfi Saltuk Demir, Şua Sümer, Nebahat Dikici, Serap Özçimen, Ahmet Çağkan İnkaya. [NAİF KRONİK HEPATİT B HASTALARININ BİR YILLIK 245 MG/GÜN TENOFOVİR DİSOPROKSİL FUMARATE TEDAVİ SONUÇLARININ DEĞERLENDİRİLMESİ]. Nobel Med 2013; 9(2): 57-62, Turkish. -
Vancouver/ICMJE Style
Nazlım Aktuğ Demir, Servet Kölgelier, Lütfi Saltuk Demir, Şua Sümer, Nebahat Dikici, Serap Özçimen, Ahmet Çağkan İnkaya. [NAİF KRONİK HEPATİT B HASTALARININ BİR YILLIK 245 MG/GÜN TENOFOVİR DİSOPROKSİL FUMARATE TEDAVİ SONUÇLARININ DEĞERLENDİRİLMESİ]. Nobel Med (2013); 9(2): 57-62, [cited Mayıs 24, 2021], Turkish. -
Harvard Style
Nazlım Aktuğ Demir, Servet Kölgelier, Lütfi Saltuk Demir, Şua Sümer, Nebahat Dikici, Serap Özçimen, Ahmet Çağkan İnkaya. (2013) [NAİF KRONİK HEPATİT B HASTALARININ BİR YILLIK 245 MG/GÜN TENOFOVİR DİSOPROKSİL FUMARATE TEDAVİ SONUÇLARININ DEĞERLENDİRİLMESİ]. Nobel Med, 9(2): 57-62, Turkish.